PARACRINE INDUCTION OF EPITHELIAL-MESENCHYMAL TRANSITION BETWEEN COLORECTAL CANCER CELLS AND ITS SUPPRESSION BY A P53/MIR-192/215/NID1 AXISSUMMARY

Paracrine Induction of Epithelial-Mesenchymal Transition Between Colorectal Cancer Cells and its Suppression by a p53/miR-192/215/NID1 AxisSummary

Background & Aims: Intratumor heterogeneity is a common feature of colorectal cancer (CRC).Here, we analyzed whether mesenchymal-like CRC cells promote the progression of epithelial-like CRC cells via paracrine mechanisms.Methods: Six CRC cell lines that show an epithelial phenotype were treated with conditioned media (CM) from CRC cell lines that

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Intraneural stimulation elicits discrimination of textural features by artificial fingertip in intact and amputee humans

Restoration of touch after hand amputation is a desirable feature of ideal prostheses.Here, we show that texture discrimination can be artificially provided in human subjects by Seasoning implementing a neuromorphic real-time mechano-neuro-transduction (MNT), which emulates to some extent the firing dynamics of SA1 cutaneous afferents.The MNT proce

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